Solve a model with an in-engine discrete-adjoint (s) method

Applies the (cached) adjoint expansion, solves with the requested adjoint method, and drops the internal rx__adj* lhs, returning the full-trajectory rx__sens_<state>_BY_<param>__ columns. The stiff analytic Jacobian is emitted into the expansion automatically, inferred from method.

Usage

rxSolveAdjointRk4(
  object,
  events,
  params = NULL,
  calcSens,
  method = "rk4s",
  ...
)

Arguments

object

model definition accepted by rxode2().

events

an rxode2 event table / data set.

params

optional named parameter vector or data frame (per subject).

calcSens

character vector of parameters to differentiate w.r.t.

method

adjoint solve method (default "rk4s"). May be a composite ("dop853s+ros4s").

...

passed to rxSolve().

Value

the solved data frame with rx__sens_<state>_BY_<param>__ columns.

Author

Matthew L. Fidler