Skip to contents

Set random effects and residual error to zero

Source: R/piping-ini.R
zeroRe.Rd

Set random effects and residual error to zero

Usage

zeroRe(object, which = c("omega", "sigma"), fix = TRUE)

Arguments

object

The model to modify

which

The types of parameters to set to zero

fix

Should the parameters be fixed to the zero value?

Value

The object with some parameters set to zero

See also

Other Initial conditions: ini.rxUi()

Author

Bill Denney

Examples

one.compartment <- function() {
  ini({
    tka <- log(1.57); label("Ka")
    tcl <- log(2.72); label("Cl")
    tv <- log(31.5); label("V")
    eta.ka ~ 0.6
    eta.cl ~ 0.3
    eta.v ~ 0.1
    add.sd <- 0.7
  })
  model({
    ka <- exp(tka + eta.ka)
    cl <- exp(tcl + eta.cl)
    v <- exp(tv + eta.v)
    d/dt(depot) = -ka * depot
    d/dt(center) = ka * depot - cl / v * center
    cp = center / v
    cp ~ add(add.sd)
  })
}
zeroRe(one.compartment)
#>  
#>  
#>  ── rxode2-based free-form 2-cmt ODE model ────────────────────────────────────── 
#>  ── Initalization: ──  
#> Fixed Effects ($theta): 
#>       tka       tcl        tv    add.sd 
#> 0.4510756 1.0006319 3.4499875 0.0000000 
#> 
#> Omega ($omega): 
#>        eta.ka eta.cl eta.v
#> eta.ka      0      0     0
#> eta.cl      0      0     0
#> eta.v       0      0     0
#> attr(,"lotriFix")
#>        eta.ka eta.cl eta.v
#> eta.ka   TRUE  FALSE FALSE
#> eta.cl  FALSE   TRUE FALSE
#> eta.v   FALSE  FALSE  TRUE
#> 
#> States ($state or $stateDf): 
#>   Compartment Number Compartment Name
#> 1                  1            depot
#> 2                  2           center
#>  ── μ-referencing ($muRefTable): ──  
#>   theta    eta level
#> 1   tka eta.ka    id
#> 2   tcl eta.cl    id
#> 3    tv  eta.v    id
#> 
#>  ── Model (Normalized Syntax): ── 
#> function() {
#>     ini({
#>         tka <- 0.451075619360217
#>         label("Ka")
#>         tcl <- 1.00063188030791
#>         label("Cl")
#>         tv <- 3.44998754583159
#>         label("V")
#>         add.sd <- fix(0, 0)
#>         eta.ka ~ fix(0)
#>         eta.cl ~ fix(0)
#>         eta.v ~ fix(0)
#>     })
#>     model({
#>         ka <- exp(tka + eta.ka)
#>         cl <- exp(tcl + eta.cl)
#>         v <- exp(tv + eta.v)
#>         d/dt(depot) = -ka * depot
#>         d/dt(center) = ka * depot - cl/v * center
#>         cp = center/v
#>         cp ~ add(add.sd)
#>     })
#> }