Event translation for rxode2

Event translation for rxode2

Usage

etTrans(
  inData,
  obj,
  addCmt = FALSE,
  dropUnits = FALSE,
  allTimeVar = FALSE,
  keepDosingOnly = FALSE,
  combineDvid = NULL,
  keep = character(0),
  addlKeepsCov = FALSE,
  addlDropSs = TRUE,
  ssAtDoseTime = TRUE,
  iCov = NULL
)

Arguments

inData

Data frame to translate

obj

object where model variables can be extracted from

addCmt

Add compartment to data frame (default FALSE).

dropUnits

Boolean to drop the units (default FALSE).

allTimeVar

Treat all covariates as if they were time-varying

keepDosingOnly

keep the individuals who only have dosing records and any trailing dosing records after the last observation.

combineDvid

is a boolean indicating if rxode2 will use DVID on observation records to change the cmt value; Useful for multiple-endpoint nlmixr models. By default this is determined by option("rxode2.combine.dvid") and if the option has not been set, this is TRUE. This typically does not affect rxode2 simulations.

keep

This is a named vector of items you want to keep in the final rxode2 dataset. For added rxode2 event records (if seen), last observation carried forward will be used.

addlKeepsCov

This determines if the additional dosing items repeats the dose only (FALSE) or keeps the covariates at the record of the dose (TRUE)

addlDropSs

When there are steady state doses with an addl specification the steady state flag is dropped with repeated doses (when TRUE) or retained (when FALSE)

ssAtDoseTime

Boolean that when TRUE back calculates the steady concentration at the actual time of dose, otherwise when FALSE the doses are shifted

iCov

A data frame of individual non-time varying covariates to combine with the events dataset. The iCov dataset has one covariate per ID and should match the event table

Value

Object for solving in rxode2