To add additional compartments to the model
Usage
addComp(
model,
numPeripheral,
central = "central",
depot = "depot",
peripheralComp = "peripheral",
vp = "vp",
vc = "vc",
q = "q"
)Arguments
- model
The model as a function
- numPeripheral
number of peripheral compartments to be added to the model
- central
a character vector representing the central compartment
- depot
a character vector representing the depot compartment
- peripheralComp
A character vector representing the prefix of peripheral compartments
- vp
parameter representing the peripheral volume of the first (central) compartment and the prefix of the other compartments
- vc
parameter representing the central volume of the first (central) compartment and the prefix of the other compartment's volume
- q
inter-compartmental clearance parameter or prefix (depending on the model)
Examples
readModelDb("PK_1cmt_des") |>
addComp(1)
#>
#>
#> ℹ promote `lvp` to population parameter with initial estimate 0.05
#> ℹ change initial estimate of `lvp` to `0.05`
#> ℹ promote `lq` to population parameter with initial estimate 0.05
#> ℹ change initial estimate of `lq` to `0.05`
#> ── rxode2-based free-form 2-cmt ODE model ──────────────────────────────────────
#> ── Initalization: ──
#> Fixed Effects ($theta):
#> lka lcl lvc propSd lvp lq
#> 0.45 1.00 3.45 0.50 0.05 0.05
#>
#> States ($state or $stateDf):
#> Compartment Number Compartment Name
#> 1 1 central
#> 2 2 peripheral1
#> ── Model (Normalized Syntax): ──
#> function() {
#> description <- "One compartment PK model with linear clearance using differential equations"
#> dosing <- c("central", "depot")
#> ini({
#> lka <- 0.45
#> label("Absorption rate (Ka)")
#> lcl <- 1
#> label("Clearance (CL)")
#> lvc <- 3.45
#> label("Central volume of distribution (V)")
#> propSd <- c(0, 0.5)
#> label("Proportional residual error (fraction)")
#> lvp <- 0.05
#> lq <- 0.05
#> })
#> model({
#> ka <- exp(lka)
#> cl <- exp(lcl)
#> vc <- exp(lvc)
#> vp <- exp(lvp)
#> q <- exp(lq)
#> k12 <- q/vc
#> k21 <- q/vp
#> d/dt(central) <- ka * depot - kel * central + k21 * peripheral1 -
#> k12 * central
#> d/dt(peripheral1) <- k12 * central - k21 * peripheral1
#> Cc <- central/vc
#> Cc ~ prop(propSd)
#> })
#> }