Warfarin PK/PD data
Format
A data frame with 519 rows and 9 columns
- id
Patient identifier (n=32)
- time
Time (h)
- amt
Total drug administered (mg)
- dv
Warfarin concentrations (mg/L) or PCA measurement
- dvid
Dependent identifier Information (cp: Dose or PK, pca: PCA, factor)
- evid
Event identifier
- wt
Weight (kg)
- age
Age (yr)
- sex
Sex (male or female, factor)
Source
Funaki T, Holford N, Fujita S (2018). Population PKPD analysis using nlmixr2 and NONMEM. PAGJA 2018
References
O'Reilly RA, Aggeler PM, Leong LS. Studies of the coumarin anticoagulant drugs: The pharmacodynamics of warfarin in man. Journal of Clinical Investigation 1963; 42(10): 1542-1551
O'Reilly RA, Aggeler PM. Studies on coumarin anticoagulant drugs Initiation of warfarin therapy without a loading dose. Circulation 1968; 38: 169-177.
See also
Other nlmixr2 datasets:
Bolus_1CPTMM,
Bolus_1CPT,
Bolus_2CPTMM,
Bolus_2CPT,
Infusion_1CPTMM,
Infusion_1CPT,
Infusion_2CPTMM,
Infusion_2CPT,
Oral_1CPTMM,
Oral_1CPT,
Oral_2CPTMM,
Oral_2CPT,
Wang2007,
mavoglurant,
nimoData,
nmtest,
pheno_sd,
rats,
theo_md,
theo_sd,
wbcSim