This is from a PK study in neonatal infants. They received multiple doses of phenobarbital for seizure prevention.
Format
A data frame with 744 rows and 8 columns
- ID
Infant ID
- TIME
Time (hr)
- AMT
Dose (ug/kg)
- WT
Weight (kg)
- APGR
A 5-minute Apgar score to measure infant health
- DV
The concentration of phenobarbitol in the serum (ug/mL)
- MDV
If the dependent variable (DV) is missing; 0 for observations, 1 for doses
- EVID
Event ID
Source
Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.23)
Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, Chapman and Hall, London. (section 6.6)
Grasela and Donn (1985), Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data, Developmental Pharmacology and Therapeutics, 8, 374-383.
Boeckmann, A. J., Sheiner, L. B., and Beal, S. L. (1994), NONMEM Users Guide: Part V, University of California, San Francisco.
Littell, R. C., Milliken, G. A., Stroup, W. W. and Wolfinger, R. D. (1996), SAS System for Mixed Models, SAS Institute, Cary, NC.
Details
The data were originally given in Grasela and Donn(1985) and are analyzed in Boeckmann, Sheiner and Beal (1994), in Davidian and Giltinan (1995), and in Littell et al. (1996).
See also
Other nlmixr2 datasets:
Bolus_1CPTMM,
Bolus_1CPT,
Bolus_2CPTMM,
Bolus_2CPT,
Infusion_1CPTMM,
Infusion_1CPT,
Infusion_2CPTMM,
Infusion_2CPT,
Oral_1CPTMM,
Oral_1CPT,
Oral_2CPTMM,
Oral_2CPT,
Wang2007,
mavoglurant,
nimoData,
nmtest,
rats,
theo_md,
theo_sd,
warfarin,
wbcSim