Nudge exactly-zero theta initial estimates off zero (FOCEi family)

FOCEi scales a linear parameter by its native magnitude `|init|`, which is `0` (no scale) when a population parameter is initialized at exactly `0` (the parameter then freezes). This hook moves every estimated, non-fixed `theta` whose initial estimate is exactly `0` to `+zeroTheta` when that is within its bounds, otherwise `-zeroTheta`; if neither is within the bounds it errors. Only runs for the FOCEi family (a `foceiControl`), and runs before `.preProcessBoundedTransform` so the nudged value is what gets transformed.

Usage

.preProcessZeroTheta(ui, est, data, control)

Arguments

ui

rxode2 ui model

est

estimation method (all methods are shown by `nlmixr2AllEst()`). Methods can be added for other tools

data

nlmixr data

control

The estimation control object. These are expected to be different for each type of estimation method

Value

list with the ui (possibly modified)

Author

Matthew L. Fidler