Setup a nonlinear system for optimization
Arguments
- par
A named vector of initial estimates to setup the nonlinear model solving environment. The names of the parameter should match the names of the model to run (not `THETA[#]` as required in the `modelInfo` argument)
- ui
rxode2 ui model
- data
rxode2 compatible data for solving/setting up
- modelInfo
A list with `predOnly` (predictions-only model in terms of `THETA[#]`/`DV`), `eventTheta` (0/1 per THETA flagging event-related parameters that need Shi2021 finite differences, same length as `par`), and `thetaGrad` (needed when solveType != 1; gives value/gradient per THETA). See `ui$nlmSensModel` or `ui$nlmRxModel` for examples.
- control
control structure; required: `rxControl`, `stickyRecalcN`, `maxOdeRecalc`, `odeRecalcFactor`. Optional: `solveType`, `eventType`, `shi21maxFD`, `shiErr`, `optimHessType`, `shi21maxHess`, `hessErr`, `useColor`, `printNcol`, `print`, `normType`, `scaleType`, `scaleCmin`, `scaleCmax`, `scaleTo`, `scaleC`, `gradTo` (default 0 if missing).
- lower
lower bounds, will be scaled if present
- upper
upper bounds, will be scaled if present
Value
nlm solve environment; key fields: `$par.ini`, `$lower`, `$upper` (all scaled), and `$.ctl` (control structure).
